アルキンの電気化学的二酸化メチル化
Peng Xiong1, He-Huan Xu1, Jinshuai Song2
1State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, Innovation Center of Chemistry for Energy Materials and College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, People's Republic of China.
Journal of the American Chemical Society
|February 7, 2018
まとめ
新しい二酸化リチル化反応剤により,アルキンの新種の過激な二酸化リチル化が可能になる. この反応により,独特の7つの環を形成する過程で,酸化ディベンザゼピンが生成されます.
科学分野:
- 有機化学
- フッ素化学
- 合成方法論
背景:
- フッ素を含むグループを導入するための新しい合成方法の開発は,医薬品化学と材料科学において極めて重要です.
- C-C結合の形成と機能化に 独特の経路を提供している.
- ディベンザゼピンなどのフッ化ヘテロサイクル化合物の合成は,依然として活発な研究分野である.
研究 の 目的:
- アルキンの新種の過激な二酸化メチル化反応を開発する.
- 新しい安定した二酸化メチル化反応剤を 発見し合成する
- 新しい合成経路を介して酸化ディベンザゼピン形成を調査する.
主な方法:
- CF2HSO2ClとNH2NHBocから作られた新しい二酸化メチル化反応剤の発見
- 鉄素媒介による電気化学的酸化によるCF2Hの生成
- アルキン添加反応に続いて7つの環を形成する同解性芳香的置換反応.
主要な成果:
- アルキンの放射性二酸化塩素の 開発に成功
- 新しい反応剤CF2HSO2NHNHBocは空気に安定し,固体であり,簡単に作られます.
- この反応は,新しい7つの環の循環により,効率的に酸化ディベンザゼピンを生成する.
結論:
- 新しい実用的な二酸化メチル化反応剤が合成されました.
- フッ素ジベンゼピンへのアクセスのための革新的な合成戦略が確立されています.
- この研究は,過激な二酸化アルファルメチル化と有価なフッ素ヘテロサイクルの合成のためのツールボックスを拡張します.
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