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Updated: Feb 14, 2026

Fluorescence Based Primer Extension Technique to Determine Transcriptional Starting Points and Cleavage Sites of RNases In Vivo
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Fluorescence Based Primer Extension Technique to Determine Transcriptional Starting Points and Cleavage Sites of RNases In Vivo

Published on: October 31, 2014

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下流オリゴヌクレオチドによる非酵素RNAプライマー拡張の強化カタリシスの構造的根拠

Wen Zhang1,2, Chun Pong Tam1,3, Lijun Zhou1,2

  • 1Howard Hughes Medical Institute and Center for Computational and Integrative Biology, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

Journal of the American Chemical Society
|February 8, 2018
PubMed
まとめ

ダウンストリームオリゴヌクレオチドは,活性化されたモノメアを安定させることで,非酵素RNA複製を強化する. この発見は,プリバイオティックRNAの複製メカニズムと早期RNAの進化におけるヘルパーオリゴヌクレオチドの役割に光を当てています.

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