関連する実験動画
Updated: Feb 14, 2026

08:02
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
5.9K
c-MAF依存の調節性T細胞は,腸内病原体に対する免疫的耐性を媒介する
Mo Xu1, Maria Pokrovskii1, Yi Ding2
1Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.
Nature
|February 8, 2018
まとめ
病原菌ヘリコバクター・ヘパティカスに対する宿主耐性は,炎症性Tヘルパー17 (TH17) 細胞を抑制し,自己免疫疾患を予防するc-MAF依存の調節性T細胞 (iTreg) に依存しています.
科学分野:
- 免疫学
- 微生物学
- 遺伝学
背景:
- 自己免疫疾患には 微生物と宿主の遺伝的要因が関係しています
- ヘリコバクターの種のように 慢性炎症や病原性T細胞を引き起こします
- 健康な個体における病原性T細胞を抑制するメカニズムは不明である.
研究 の 目的:
- 病原生物に対する宿主耐性メカニズムを調査する.
- 調節性T細胞 (Tregs) がTヘルパー17 (TH17) 細胞の反応を制御する役割を特定する.
- トレグ機能と免疫ホメオスタシスに関与する転写因子を明らかにする.
主な方法:
- 野生型とIL-10欠乏したマウスのヘリコバクターヘパティカスのコロニー化.
- RORγt+FOXP3+ iTregとTH17細胞を含むT細胞の微分化の分析
- トレグ細胞における転写因子c- MAFとRORγtの遺伝的不活性化
主要な成果:
- 野生型のマウスのRORγt発現するiTreg細胞を誘導し,TH17細胞を抑制した.
- IL-10欠乏したマウスは,H. hepaticusのコロニー化時にコリトゲンTH17細胞の拡張を示した.
- iTregの機能が低下し,TH17細胞の蓄積と自発性大腸炎を引き起こした.
- TregsにおけるRORγt不活性化は,免疫バランスに最小限の影響を及ぼし,炎症を引き起こしませんでした.
結論:
- H. hepaticusに対する宿主耐性は,TH17細胞を抑制するc-MAF依存 iTreg細胞によって媒介される.
- このc-MAF依存型 iTreg-TH17 ホメオスタシスの調節不全により,病原体反応性T細胞が炎症性腸疾患を誘発することが可能になる.
さらに関連する動画
関連する概念動画
Cis-regulatory Sequences
11.9K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.9K
Cis-regulatory Sequences
4.2K
4.2K
Immunological Memory
17.1K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.1K
Global Regulatory Systems
732
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
732
Frequency-dependent Selection
24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Contact-dependent Signaling
47.7K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
47.7K

