後頭上皮質は感覚の歴史を表し,行動への影響を媒介する

Athena Akrami^1,2,3, Charles D Kopec^1,2, Mathew E Diamond⁴

¹Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA.

Nature

|February 8, 2018

まとめ

前頭皮質 (PPC) は感覚情報を処理する上で重要ですが作業記憶自体には重要ではありません過去の刺激が現在の決定に与える影響を減らし,PPCを静止させることで,作業のパフォーマンスを改善しました.

科学分野:

神経科学
認知科学
計算神経科学

背景:

過去の刺激統計は作業記憶と知覚に大きく影響します
過去の感覚経験の利用に基づく神経のメカニズムはほとんど不明です

研究の目的:

前回の刺激情報を表現し利用する神経領域を特定する.
感覚経歴の処理における後部頭皮質 (PPC) の役割を調査する.

主な方法:

ネズミは聴覚的パラメトリックの作業記憶のタスクで訓練されました
PPCの因果的な役割を評価するために,光遺伝的静音化が使用されました.
神経活動を分析するために,電気生理学的記録が行われました.

主要な成果:

PPCを静音化すると,予期せぬほどの性能が向上し,以前の感覚刺激の影響が減った.
PPCニューロンは,現在の試験よりも以前の試験に関するより多くの情報を示しました.
PPCの刺激経歴と行動効果との間には相関関係があることがわかりました.

結論:

PPCは感覚刺激の歴史を処理する上で重要な役割を果たしますが作業記憶機能には欠かせません
先の情報を活用する PPC の役割は,知覚と記憶を研究するための新しい道を開きます.

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