配列アルキレーションとカルボニルアリレーションによる1,3-ブタジエンのエナンチオセレクティブの1,2-機能化
1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, People's Republic of China.
Journal of the American Chemical Society
|February 10, 2018
まとめ
新しいクロム/コバルト二金属触媒は,3つの成分結合反応を可能にします. この方法は効率的に分子にフッ素を導入し,高い選択性を持つ有価なフッ素ホモアリルアルコールを生成します.
科学分野:
- 有機化学
- キャタリシス
- フッ素化学
背景:
- 三要素結合反応は複雑な分子合成のための強力なツールです.
- 有機分子にフッ素を導入すると その性質が大きく変化します
- 化のための選択的触媒方法の開発は,依然として課題です.
研究 の 目的:
- 高度にエナチオセレクティブの3つのコンポーネントの結合反応を開発する.
- この変換のためにCr/Coバイメタリック触媒システムを利用する.
- ホモアリルアルコールにフッ素機能を導入する.
主な方法:
- Cr/Coバイメタリック触媒システムを使用しています.
- アルキルハリドとアルデヒドと反応する.
- 反応条件を最適化して,エナチオセレクティブ性とダイアステレオセレクティブ性.
主要な成果:
- 高度にエナチオセレクティブの3つのコンポーネントの結合反応を達成しました.
- 1,3-ブタジーン,アルキルハリド (フッ素化および非フッ素化) とアルデヒドをうまく結合した.
- ホモアリルアルコールにフッ素機能を直接導入することが示されている.
- 高い反ダイアステレオとエナンチオセレクティブコントロールを持つ製品.
結論:
- フッ化ホモアリルアルコールを合成するための新しい効率的な触媒システムが開発されました.
- この方法は,すぐに入手可能な出発材料を使用して,特権的なフッ素群を簡単に組み込むことを可能にします.
- この戦略は,エナチオメリックに富んだフッ素化合物へのアクセスに有益なアプローチを提供します.
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