染色体転移はバチルス・フォレスポールを膨らませ,細胞形態に影響を与える
Javier Lopez-Garrido1, Nikola Ojkic2, Kanika Khanna1
1Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Cell
|February 10, 2018
まとめ
細菌の細胞の形状の変化は,細胞壁の成長ではなく,膜合成と染色体の動きによって引き起こされる. 膨らんだバクテリアのヌクレオイドは 胞子を膨らませ 最終的な卵状の形を決めます
科学分野:
- 微生物学
- 細胞生物学
- バイオ物理学
背景:
- 細菌細胞の形状の決定は複雑で,完全に理解されていません.
- 細胞形態は,細胞の構成要素の物理化学的性質から生じる.
- プログラムされた細胞の形状の変化は,細菌の胞胎化中に起こります.
研究 の 目的:
- バチルス・サブティリスの分泌過程で 細菌細胞の形状が変化するメカニズムを調査する.
- 形質変異を促す様々な細胞成分とプロセスの貢献を決定する.
主な方法:
- 遺伝学
- タイムラプス顕微鏡
- クリオ電子トモグラフィー
- 数学的モデリング
主要な成果:
- 前胞の成長は膜合成とSpoIIIE媒介の染色体転移に依存する.
- ペプチドグリカンとタンパク質の合成は,胞子の成長には必要ありません.
- 水素化された核細胞の腫れは 核細胞の膨張と再形成を促し リボソームを移動させます
結論:
- 細胞の構成要素の間の生理学的相互作用が 細菌の細胞形態学を支配する.
- 核状の腫れは細菌の胞子形成と細胞の形状の決定における重要なメカニズムである.
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