細胞の種類と脳血管のゾナーションの分子アトラス

¹Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Blickagången 6, SE-141 57 Huddinge, Sweden.
²Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85 Uppsala, Sweden.
³Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin 300052, China.
⁴Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers väg 3, SE-171 77 Stockholm, Sweden.
⁵Inserm U1171, University of Lille, CHU, Memory Center, Distalz, F-59000 Lille, France.
⁶Department of Bioinformatics, Zhongyuan Union Genetic Technology Co., Ltd., No.45, the 9th East Road, Tianjin Airport Economic Area, Tianjin 300304, China.
⁷Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, FI-00014 Helsinki, Finland.
⁸Division of Neurosurgery, Zürich University Hospital, Zürich University, Zürich, CH-8091, Switzerland.
⁹Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
¹⁰AMED-CREST, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

⁰Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Blickagången 6, SE-141 57 Huddinge, Sweden.

まとめ

この研究では,単細胞トランスクリプトミクスを用いて脳血管および関連細胞を定義し,異なる内皮細胞および壁細胞連続体と新しい細胞タイプを明らかにします. この研究により哺乳類の血管系を分子レベルで理解できるようになりました

まとめ