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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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Published on: June 27, 2025

808

NMDA型グルタミン酸受容体の活性化により,血管再構成と肺動脈高血圧が促進される

Sébastien J Dumas1,2, Gilles Bru-Mercier1,2, Audrey Courboulin1,2

  • 1INSERM UMR-S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France (S.J.D., G.B.-M., A.C., M.Q., C.R.-M, F.A., M.K.N., B.R., E.G., M.-C.V., M.V., N.R., P.D., E.F., F.P., M.H., S.C.-K.).

Circulation
|February 16, 2018
PubMed
まとめ

肺動脈高血圧 (PAH) は,代謝変化によって引き起こされる血管の改造を伴う. この研究では,グルタミン酸-N-メチル-D-アスパルテート受容体 (NMDAR) 軸がPAHで調節不良であることを明らかにし,抗リモデリング治療の潜在的な治療標的としてNMDARを示唆しています.

キーワード:
NMDA受容体についてエンドセリン-1グルタミン酸血小板由来成長因子肺動脈高血圧滑らかな筋肉細胞血管の改造

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