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Updated: Feb 14, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

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C1-IgG1の構造は,危険パターンの認識が補完体をどのように活性化するかについての洞察を提供します.

Deniz Ugurlar1, Stuart C Howes2, Bart-Jan de Kreuk3

  • 1Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.

Science (New York, N.Y.)
|February 17, 2018
PubMed
まとめ

この研究は,C1複合体が抗体と結合することによって,補完カスケードを開始する方法を明らかにしています. 低温電子顕微鏡では,抗体結合時にC1qアームの凝縮とプロテアスの再配置が示され,免疫反応のトリガーは明らかになった.

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