新型アディポキン,FAM19A5は,スフィンゴシン-1-リン酸受容体2を通して,傷害後のネオインティマ形成を抑制する
Yingbao Wang1, Dixin Chen1,2, Yan Zhang2
1Department of Physiology and Pathophysiology (Y.W., D.C., S.Z., B.Y., L.Z., G.Z., B.M., Z.C., N.X., Z.L., X.W., Y.F., W.K.).
Circulation
|February 18, 2018
まとめ
新しく発見されたアディポキンは,配列相似性のあるFamily 19,メンバーA5 (FAM19A5) で,血管損傷反応を抑制する. 肥満におけるFAM19A5の低下は心臓代謝疾患に寄与する可能性があります.
科学分野:
- 内分泌学
- 心血管生物学
- 分子生物学
背景:
- 肥満は心臓血管疾患の 重要な危険因子ですが その背後にあるメカニズムは 十分に理解されていません
- アディポキンは脂肪組織からのシグナル伝達分子で 肥満に関連する心臓血管合併症に関与しています
- 配列相似性19の新型アディポキンファミリー,メンバーA5 (FAM19A5) が特定され,血管病理におけるその役割は未知のものである.
研究 の 目的:
- 新型アディポキンFAM19A5が損傷後の血管病理を調節する機能を調査する.
- FAM19A5が血管細胞に作用する分子機構と受容体を特定する.
主な方法:
- 分子生物学技術を用いたFAM19A5の分泌と発現の特徴
- ネズミとネズミにおける風船とワイヤーの損傷モデルを含むインビボ試験で,ネオインティマの形成を評価する.
- FAM19A5受容体の生物情報学,結合測定,細胞信号分析を用いた識別.
主要な成果:
- FAM19A5は脂肪組織に発現する分泌タンパク質で,肥満では抑制されます.
- FAM19A5の過剰発現は,血管の滑らかな筋肉細胞の増殖,移動,およびネオインティマの形成を抑制しました.
- Sphingosine-1-phosphate受容体2 (S1PR2) は,FAM19A5の機能的受容体として特定され,G12/13-RhoA経路を通じてその効果を媒介する.
結論:
- 新型アディポキンFAM19A5は,S1PR2-G12/13-RhoAシグナル軸を通して,傷害後のネオインティマの形成を阻害する.
- 肥満におけるFAM19A5のダウンレギュレーションは,心臓代謝疾患の発生に寄与する要因である可能性があります.
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