心臓 不全 は 循環 要因 に よっ て 腫瘍 の 成長 を 刺激 する
Wouter C Meijers1, Manuel Maglione2, Stephan J L Bakker3
1Department of Cardiology (W.C.M., D.J.v.V., B.D.W., P.v.d.M., H.H.W.S., R.A.d.B.).
Circulation
|February 21, 2018
まとめ
心不全 (HF) は,がんのリスクの増加と関連しています. この研究はHFが 心臓の要因によって腫瘍の成長を促進し,HFが癌のリスク要因であることを示唆しています.
科学分野:
- 心臓病科
- 腫瘍学
- 翻訳医学
背景:
- 心不全 (HF) の生存率の改善は,がんを含む非心疾患による死亡につながる.
- HFと癌の発症の間の潜在的な因果関係を調査することは極めて重要です.
研究 の 目的:
- 心不全 (HF) ががん発症に因果的に影響するかどうかを判断する.
- 癌の発生に寄与する心臓系因子を特定する.
主な方法:
- 腫瘍の成長を評価するために,誘発性心筋梗塞のAPCミンマウスを使用した.
- ヘテロトピック心臓移植を用いて,血動力学的障害からHFの影響を隔離した.
- 分析された候補分泌タンパク質とその結腸がん細胞への影響
- 一般集団における新発がんと相関する心臓および炎症バイオマーカー.
主要な成果:
- 心不全はマウスの腸内腫瘍の負荷を 2.4 倍に増加させた.
- 左心室機能障害と傷跡の重さは 腫瘍の成長と相関しています
- タンパク質の増加 (セルピンA3,フィブロネクチンなど) serpinA3は結腸がん細胞の増殖を促した.
- 心臓と炎症のバイオマーカーは ヒトの新発がんを予測しました
結論:
- 心不全 (HF) の存在は,血液動力学的要因とは無関係に腫瘍の成長を促進する.
- 心臓が分泌する要因は,HFと癌との関連を媒介する可能性があります.
- HFの診断は,発生がんの危険因子として考慮されるべきです.
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