女性における冠動脈疾患の代謝予測因子
Nina P Paynter1, Raji Balasubramanian2, Franco Giulianini3
1Division of Preventive Medicine (N.P.P., F.G., J.E.M., N.R.C., C.M.A., K.M.R.) npaynter@partners.org.
Circulation
|February 21, 2018
まとめ
メタボロミックプロファイリングは,C34: 2ヒドロキシホスファティディルコリンを含む酸化脂質を,女性における冠動脈疾患 (CHD) リスクの主要な予測因子として特定した. この発見は,脂質酸化と心血管疾患との関係を強調しています.
科学分野:
- 心血管疾患の研究
- メタボロミクス
- リピドミクス
背景:
- メタボロミックプロファイリングは冠動脈疾患 (CHD) の予測に有望である.
- 代謝の危険因子は男性よりも女性の心臓病と強く関連しています
- 女性の心臓病の予測に関するメタボロミックデータは限られている.
研究 の 目的:
- 閉経後の女性の冠動脈疾患 (CHD) の新しい代謝生物マーカーを特定する.
- 特定の代謝産物とCHDリスクの関連性を検証する.
- 脂質酸化と心臓病の関係を探るため
主な方法:
- 液体染色体-タンデム質量スペクトロメトリを371の代謝物質のメタボロミックプロファイリングに使用した.
- 閉経後の女性の発見と検証セット (症例と対照群) を分析した.
- 男性と女性を含む男女のデータセットで再現された結果
主要な成果:
- 主に酸化した脂質である8つの代謝物は,CHDの症例において有意に失調した.
- 酸化したフォスフォリピドC34: 2は心臓病のリスクを強く予測しました (確率の4. 7倍).
- C34: 2ヒドロキシフォスファティディルコリンは,心臓病の予測の精度を改善し,女性ではより強い関連性を示した.
結論:
- 冠動脈疾患 (CHD) の既知の代謝物質の予測を複製した.
- CHDの新しい代謝体マーカー,特に酸化脂質が特定されました.
- 脂質の酸化と,その後の心臓病の発生との関連を裏付けました.
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