自発的早産と将来の母性心血管疾患の関連
Margo B Minissian1,2,3, Sarah Kilpatrick4, Jo-Ann Eastwood3
1Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute (M.B.M., J.W., C.L.S., C.N.B.M.) MinissianM@cshs.org.
Circulation
|February 21, 2018
まとめ
spontaneous preterm delivery (sPTD) は,将来の心血管疾患 (CVD) のリスクを示唆する可能性があります. 妊娠
科学分野:
- 生殖 健康
- 心血管医学
- 産婦人科
背景:
- 心血管疾患 (CVD) の既定の危険因子は知られている.
- 妊娠中の心血管反応は 母親の心血管疾患リスクの早期マーカーです
- spontaneous preterm delivery (sPTD) は,母親のCVD死亡のリスクが3倍に増加している.
研究 の 目的:
- sPTDと将来の母性CVDリスクとの関連を批判的に評価する.
- CVDの危険因子,炎症バイオマーカー,およびsPTDに関連した血管機能障害を調査する.
- sPTDと将来のCVDリスクの増加を結びつけるメカニズムを理解する.
主な方法:
- このレビューは,既存の文献を批判的に評価しています.
- 心血管疾患の危険因子,炎症性バイオマーカー,血管機能障害 (内皮機能,動脈硬化) に焦点を当てています.
- これらの要因をsPTDと結びつけるメカニズムを調べる.
主要な成果:
- sPTDは,将来の母性心血管疾患による死亡リスクの有意な増加に関連しています.
- 妊娠中の心臓血管反応は,早期の生理学的ストレステストとして機能する.
- 潜在的リンクにはCVDリスク要因,炎症,血管機能不全が含まれます.
結論:
- sPTDと将来の母性CVDリスクとの関連は,妊娠を潜在的なスクリーニング期間として強調しています.
- そのメカニズムを明らかにするためにさらなる研究が必要である.
- これらの関連性を理解することで,心臓病のリスクのある女性に対する早期の介入を促すことができます.
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