心筋動中の電気機械的渦状フィラメント

J Christoph^1,2,3, M Chebbok^2,4, C Richter^1,2,4

¹Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.

Nature

|February 22, 2018

まとめ

この研究では超音波を用いて心臓の3D機械的スクロール波を視覚化し電気信号と共に心臓の動におけるその役割を明らかにしましたこれらの発見は心律不整の診断と治療に新たな道を開きます

科学分野:

心臓病科
バイオ物理学
医療用イメージング

背景:

渦のような回転する波が刺激可能なシステムで複雑なパターンを駆動します
3Dスクロール波のフィラメントのような相異性は心拍不良の鍵です
心臓組織におけるスクロール波の 3Dダイナミクスを理解することは極めて重要なことですが難しいことです

研究の目的:

収縮する心臓の壁の中の機械的な回転波の3D空間空間動態を視覚化するために
心筋動中の機械的および電気的相異変の共存と相互作用を調査する.
メカニカル・フェーズ・シンギュラリティのダイナミクスを用いて心臓発作を特徴づける.

主な方法:

高解像度4D超音波ベースのストレインイメージングを使用して,3D機械スクロール波を観察しました.
膜ポテンシャル,細胞内カルシウム,および機械的収縮を同時に測定した.
分析された軌跡,トポロジカルチャージ,および電気的および機械的相奇異の寿命.

主要な成果:

心臓の壁の奥深くにある 3D 機械的なスクロール波とファイラメントのような相の特異性を視覚化しました
観測された機械的相異性と,心動中の電気的相異性.
電気と機械の相異性との複雑な相互作用を証明した.

結論:

心筋動は,心室壁から発生する機械的相奇異の3D空間時間動態によって特徴付けられます.
電気と機械の相異性はダイナミックに相互作用します
この発見は,心臓動脈不律に対する新しい非侵襲的診断および治療戦略につながる可能性があります.

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