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Updated: Feb 14, 2026

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バイアスアゴニスト結合ヒトGLP-1受容体-G複合体のフェーズプレート冷凍-EM構造

Yi-Lynn Liang1, Maryam Khoshouei2, Alisa Glukhova1

  • 1Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.

Nature
|February 22, 2018
PubMed
まとめ

グルカゴン型ペプチド-1 (GLP-1) 受容体に関する構造的な洞察は,エクセンジン-P5のようなバイアスペプチドが受容体とGタンパク質とどのように異なる相互作用するかを明らかにする. この理解は2型糖尿病と肥満の治療法を 開発する上で鍵となるものです

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