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短いG1相による内遺伝的起源は,腫瘍遺伝子の誘発によるDNA複製ストレスの根底にある

Morgane Macheret1, Thanos D Halazonetis1

  • 1Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland.

Nature
|February 22, 2018
PubMed
まとめ

CCNE1やMYCのような腫瘍遺伝子は DNA複製のストレスを引き起こし,新しい遺伝子の起源を活性化します. これは複製フォークの崩壊と ゲノム不安定に繋がり 癌に繋がります

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