マウス胚における皮質内ニューロン多様性の早期出現
Da Mi1,2, Zhen Li3, Lynette Lim1,2
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE1 1UL, UK.
Science (New York, N.Y.)
|February 24, 2018
まとめ
ネズミの皮質内ニューロン発達の初期の多様性は,異なる原始細胞によって確立される. 胚前体における転写プログラムは,成人の脳に存在する様々な級の γ-アミノバター酸 (GABA) 内ニューロンを決定する.
科学分野:
- 神経科学
- 発達生物学
- ゲノミクス
背景:
- γ-アミノバター酸 (GABA) を神経伝達物質として利用する皮質内ニューロンは,哺乳類の脳における神経回路の活性を調節するために重要である.
- これらの内ニューロンは構造的・機能的多様性を有しており,複雑な脳機能に寄与しています.
- この多様性の発達の起源を理解することは 正常な脳の発達と 神経学的障害を理解するために不可欠です
研究 の 目的:
- ネズミの皮質内ニューロンの構造的・機能的多様性の起源を調査する.
- 胚のギャングリオン突起における 異なる原始細胞と新生ニューロンを特定する.
- 早期の内ニューロン分化における転写パターンの役割を明らかにする.
主な方法:
- シングル・セル・トランスクリプトミックは,発達中のマウスの脳内の細胞の遺伝子発現プロファイルを分析するために使用された.
- 分析は,ゲングリオン突起内の先駆体細胞と新規に発芽した神経細胞に焦点を当てた.
- 転写パターンは,大人の脳皮質の内部ニューロンクラスと相関していた.
主要な成果:
- 異なるタイプの原始細胞と新生の神経細胞が 胚のギャングリオン突起で特定されました
- これらの胚前駆体は 時間と空間的に制限された転写パターンを示した.
- これらの初期の転写的差異は,異なる種類の皮質内ニューロンの出現と関連していた.
結論:
- 皮質内ニューロンの多様性は,発達初期に確立され,異なる胚前駆体から発生します.
- 神経細胞が転移後すぐに存在する転写プログラムは,その後の分化を導くために重要である.
- この研究では インターニューロンの多様性は 胚の発達初期に 遺伝的にコード化されていることが示されています
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