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Updated: Feb 13, 2026

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics
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O-GlcNAcトランスファーゼは,テトラトリコペプチドリピート (TPR) スーパーヘリックスにおけるアスパラジン梯子を用いてタンパク質基質を認識する

Zebulon G Levine1, Chenguang Fan1, Michael S Melicher1

  • 1Department of Microbiology and Immunobiology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

Journal of the American Chemical Society
|February 28, 2018
PubMed
まとめ

酵素O-GlcNAcトランスファーゼ (OGT) は,TPRドメインでアスパラジンの梯子を用いて,タンパク質基板を認識し,グリコシル化します. この発見は,OGTがO-GlcNAcylationのターゲットをどのように選択するかを明確にします.

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