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薬物の負荷を増やし,追跡可能な共効果療法のための反応性酸素種に反応する放出能力を持つ陽性電荷のポリプロドラグアンフィフィール
Yan Li1, Yanhui Li1, Weihong Ji1,2
1State Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences , Beijing 100190 , China.
Journal of the American Chemical Society
|February 28, 2018
まとめ
研究者は,アルツハイマー病 (AD) 治療のために新しい追跡可能なナノ粒子を開発しました. これらのナノ粒子は 薬や神経幹細胞を運び 記憶の欠陥を改善し MRIの追跡を可能にします
科学分野:
- 生物医学工学
- ナノテクノロジー
- 神経科学
背景:
- 化学的性質が異なるため,様々な治療薬 (薬剤,核酸,ナノ粒子) の同時投与は困難です.
- 既存の媒体は,水害剤と水性剤を効果的に共封入するのに苦労しています.
- 神経退行性疾患のシナジェスティック治療のための追跡可能なシステムの開発は,依然として重要な障壁です.
研究 の 目的:
- 追跡可能な共配ナノ粒子 (NP) を作成するための陽性電荷のポリプロドラグアンフィフィルを合成する.
- 薬物と神経幹細胞 (NSC) を併用することで,アルツハイマー病 (AD) のシネジスティック治療を可能にします.
- 移植されたNSCの磁気共鳴画像 (MRI) トラッキングのために超パラマグネット酸化鉄ナノ立方体 (SPIONs) を利用する.
主な方法:
- 陽性電荷のポリプロドラッグアンフィフィルの合成
- 水性SPIONとlet-7bの反意味オリゴヌクレオチドをNPにロードする.
- 薬の放出と神経幹細胞 (NSC) に対するインビトロ評価.
- 2xTg-ADマウスモデルとMRI追跡におけるNP有効性のインビボ評価
主要な成果:
- 追跡可能なNPを成功裏に構築し,SPION,薬物,そしてlet-7bの反意味オリゴヌクレオチドを同時に提供できる.
- NPsは薬物の放出が制御され,NSCの分化が減少し,BDNFの分泌が強化されたことを示した.
- 2xTg-ADのマウスの記憶障害を 治療により大幅に回復させました
- NPs内のSPIONは,NSC移植部位と移動のMRI追跡を可能にしました.
結論:
- 陽性で充電されたポリプロドラッグアンフィフィールベースの追跡可能なNPはAD治療に有望なプラットフォームを提供します.
- このアプローチは,相乗効果療法と治療介入のリアルタイムモニタリングを容易にする.
- 開発されたNPはADやその他の神経変性疾患の治療に役立つ可能性がある.
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