ヒトの腸内微生物群を形作る際には,宿主遺伝子が環境を支配する
Daphna Rothschild1,2, Omer Weissbrod1,2, Elad Barkan1,2
1Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Nature
|March 1, 2018
まとめ
宿主の遺伝子はヒトの腸内微生物の形成に わずかな役割を果たします ダイエットや家庭での接触などの環境要因はより影響力があり 微生物群の治療法が多様な集団に 利益をもたらすことを示唆しています
科学分野:
- 人間 微生物 群 研究
- 遺伝学 と 宿主 と 微生物 の 相互作用
背景:
- 人間の腸内微生物の組成に影響を与える要因を理解することは 極めて重要です
- 宿主遺伝子の微生物多様性への正確な貢献は不明である.
研究 の 目的:
- ホストの遺伝子,祖先,腸内微生物の組成との関連を調査する.
- 微生物群の変動を促す環境要因を特定する.
- ヒトの特性を予測する微生物群のデータを評価する.
主な方法:
- 1,046人の健康な個体の遺伝子型と微生物群のデータを分析した.
- 異なる遺伝的祖先と家庭の接触における微生物組成の比較
- 食事,薬物,人類測定と微生物群の変動を相関させるための統計モデリング.
主要な成果:
- 腸内微生物の組成は 遺伝的祖先と有意な関連性を示さなかった.
- 宿主の遺伝子は微生物の組成にわずかな影響を与えた.
- 遺伝的に無縁の家族の中で 微生物群の類似性が顕著に観察された.
- ダイエット,薬物,人類測定は 微生物群の変動の20%以上を説明した.
- 微生物群のデータは 血糖値や肥満などの特徴の 予測精度を向上させました
結論:
- 環境要因,特に食事と家庭での共有は,宿主の遺伝子や祖先よりも腸内微生物の組成を決定する強い要因です.
- 微生物群のプロファイリングは,遺伝的および従来の環境データを超えて宿主特性の予測を強化します.
- 微生物群を標的とした介入は 臨床結果を改善するために 遺伝的背景が多様であることを示しています
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