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関連する概念動画

Dehydration Synthesis01:15

Dehydration Synthesis

150.5K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
150.5K
Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

38.4K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. 
38.4K
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

61.5K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.5K
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

13.4K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.4K
Total Voids in Concrete01:12

Total Voids in Concrete

502
Total voids in concrete encompass gel water volume, capillary pores, and entrapped air. Gel water (retained within the cement hydration products) and physically entrapped or adsorbed water are significant for the hydration process. For complete hydration, it's estimated that the space needed for the products of a cubic centimeter of cement doubles. Capillary pores constitute the unoccupied space within the hydrated cement paste, with their size largely influenced by the water-to-cement...
502
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

13.5K
Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
13.5K

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関連する実験動画

Updated: Feb 13, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

11.9K

ハイブリダフニフィリンBの総合成

Wenhao Zhang1, Ming Ding1, Jian Li1

  • 1State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis , Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.

Journal of the American Chemical Society
|March 2, 2018
PubMed
まとめ
この要約は機械生成です。

研究者らは,複合的なダフニフィリンアルカロイドであるハイブリダフニフィリンBの最初の完全な合成を達成しました. この突破は,合成有機化学を進めるために,後期的な分子間ダイエルス-アルダー反応を利用した.

さらに関連する動画

Synthesis and Microdiffraction at Extreme Pressures and Temperatures
07:26

Synthesis and Microdiffraction at Extreme Pressures and Temperatures

Published on: October 7, 2013

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Single Read and Paired End mRNA-Seq Illumina Libraries from 10 Nanograms Total RNA
14:49

Single Read and Paired End mRNA-Seq Illumina Libraries from 10 Nanograms Total RNA

Published on: October 27, 2011

39.7K

関連する実験動画

Last Updated: Feb 13, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

11.9K
Synthesis and Microdiffraction at Extreme Pressures and Temperatures
07:26

Synthesis and Microdiffraction at Extreme Pressures and Temperatures

Published on: October 7, 2013

11.7K
Single Read and Paired End mRNA-Seq Illumina Libraries from 10 Nanograms Total RNA
14:49

Single Read and Paired End mRNA-Seq Illumina Libraries from 10 Nanograms Total RNA

Published on: October 27, 2011

39.7K

科学分野:

  • 有機化学
  • 自然製品合成
  • 薬剤化学

背景:

  • ハイブリダフニフィリンBは11のリングと19のステレオセンターを持つ複雑なダフニフィリンアルカロイドです.
  • ハイブリダフニフィリンBの複雑な構造は,総合成に重大な課題を提示しています.

研究 の 目的:

  • ハイブリダフニフィリンBの 最初の完全合成を報告する
  • ダフニロンゲラニンBを含む主要な中間物質のスケーラブルな経路の開発
  • 遅い段階の分子間ダイエルス-アルダー反応などの新合成戦略を探求する.

主な方法:

  • ダフニロンゲランBへのスケーラブルな経路が確立された.
  • 望ましくないコップの再編成を抑制するために最適化された.
  • 合成には,サイクロペンタディエンとアスペルロシドテトラアセテート誘導体との間の遅い段階の分子間ダイエルス-アルダー反応が含まれています.
  • ディエンの形成とディエルス・アルダー反応のための1ポットプロトコルが開発された.

主要な成果:

  • ハイブリダフィリンBの最初の完全合成が成功しました.
  • ダフニウニンEとデヒドロダフニロンゲラニンBも合成された.
  • 合成は,複雑なアルカロイドの枠組みを構築する際の遅い段階の分子間ダイエルス-アルダー反応の有用性を実証した.
  • 新しい"ポットプロトコルにより,ダイエンの形成とサイクロアディションのプロセスを簡素化しました.

結論:

  • ハイブリダフニフィリンBの総合成は,天然製品合成の分野に貴重な貢献を提供します.
  • 開発された合成戦略は,他の複雑なダフニフィラムアルカロイドにアクセスする可能性を秘めています.
  • この研究は,複雑な分子構造を組み立てるためのダイエルス-アルダー反応の力を強調しています.