β2- アドレナゲン受容体媒介によるグループ2の先天性リンパ球応答の負の調節
Saya Moriyama1, Jonathan R Brestoff1,2, Anne-Laure Flamar1
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
まとめ
神経細胞は,グループ2の先天性リンパ球 (ILC2) を制御することによって,タイプ2の炎症を調節する. ILC2sのβ2 adrenergic受容体 (β2AR) はブレーキとして働き,腸と肺の過剰な炎症を防ぐ.
科学分野:
- 免疫学
- 神経科学
- 炎症に関する研究
背景:
- 2型炎症は免疫に不可欠ですが 組織損傷を引き起こす可能性があります
- グループ2の先天性リンパ球 (ILC2) は,タイプ2の炎症の主要な原動力です.
- ILC2の活性を制御する分子メカニズムはほとんど不明です.
研究 の 目的:
- ILC2機能を調節する β2 アドレナゲン受容体 (β2AR) の役割を調査する.
- ILC2媒介型炎症の神経制御を解明する.
主な方法:
- 野生型とβ2AR欠乏したマウスのILC2sの分析.
- ILC2とニューロンのコロカライゼーションを評価する免疫ヒストケミストリー
- β2ARアゴニストの体内投与
- ILC2の増殖とサイトカインの生成の評価
主要な成果:
- ネズミのILC2はβ2ARを発現し,腸内アドレナージクニューロンの近くに存在します.
- β2AR欠乏は,ILC2反応と腸と肺の2型炎症を増加させた.
- β2ARアゴニストによる治療は,ILC2の活性を抑制し,炎症を減少させた.
- β2ARシグナリングは本質的にILC2の増殖とエフェクター機能を阻害する.
結論:
- β2AR経路は細胞内的な方法でILC2応答を否定的に調節する.
- β2AR経由のニューロン信号は,ILC2誘発型の炎症を制限する規制回路を提供する.
- この研究は 炎症反応を制御する 新しい神経免疫相互作用を明らかにしています
関連する概念動画
Negative Regulator Molecules
38.6K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Receptor-mediated Endocytosis
111.5K
Overview
111.5K
Cells of the Innate Immune Response
9.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.5K
Adrenergic Receptors (Adrenoceptors): Classification
5.1K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
5.1K
Adrenergic Receptors: ɑ Subtype
3.0K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
3.0K
Adrenergic Receptors: β Subtype
3.9K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.9K


