数百万の親族を持つ人口規模の系統樹の定量分析
Joanna Kaplanis1,2, Assaf Gordon1,2, Tal Shor3,4
1New York Genome Center, New York, NY 10013, USA.
まとめ
研究者はオンラインの 系統譜データから 巨大な系統樹を構築し 人類の長寿や 移住パターンの 遺伝的要因を明らかにしました このリソースは様々な科学分野に役立つ.
科学分野:
- ゲノミクス
- 人類学
- 経済学
- 人口統計
背景:
- 拡張された系統樹の収集は,範囲とデータの制限が限られているため,困難です.
- 血統調査の熱狂的な人々は 膨大な量の公共のデータをオンラインで共有しています
- 人口スケールの系統樹は様々な科学分野に不可欠です.
研究 の 目的:
- オンラインで公開されているデータから大規模な 系統樹を作ります
- 人間の長寿の遺伝的構造を分析する
- 家族の地理的分散を調査する
主な方法:
- オンラインの家系データから 8千6百万のプロフィールを集めました
- 徹底したデータ清掃と検証を行いました
- データオーバーレイのデジタル手順を開発しました.
主要な成果:
- 13百万の個体系統を含む 集団規模の系統樹を作りました
- 人間の長寿の遺伝的構造を 分割しました
- 地理的な家族分散パターンの洞察を提供した.
結論:
- オンラインで共有された遺伝子のデータは,広範囲にわたる系統樹を構築するために利用できます.
- 生成された資源は遺伝学と人口学の研究を容易にする.
- デジタルオーバーレイ手順は,データ統合能力を強化します.
さらに関連する動画
06:56Author Spotlight: Advancements in X-ray CT Tool Chain for Tree Core Analysis
Published on: September 22, 2023
1.7K
10:40Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
Published on: December 22, 2017
11.0K
関連する概念動画
Protein Families
17.2K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...
17.2K
Gene Families
10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
10.0K
The Tree of Life - Bacteria, Archaea, Eukaryotes
39.3K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
39.3K
Relative Motion Analysis - Velocity
765
A stroke engine has a slider-crank mechanism that converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider.
When an external force is exerted, it sets the crank into a rotational movement. This, in turn, instigates the motion of the connecting rod, leading to what is referred to as a general plane motion. This process involves two key points - point A on the connecting rod...
When an external force is exerted, it sets the crank into a rotational movement. This, in turn, instigates the motion of the connecting rod, leading to what is referred to as a general plane motion. This process involves two key points - point A on the connecting rod...
765
Relative Motion Analysis - Acceleration
903
A slider-crank mechanism converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider. The movement of the slider-crank is an example of general plane motion as the fluctuating angle between the crank and the connecting rod. Consider a segment AB where point A is at the end of the slider and point B is on the diametrically opposite end to point A, on a crack. The variance in...
903
Quantitative Analysis
1.5K
Quantitative analysis is a technique for measuring the amount of specific constituents in a sample. When the sample's composition is unknown, qualitative analysis is performed first to identify its components, which ensures that the correct substances are measured during the quantitative phase.
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
1.5K
