大分子化学療法剤によるがんにおける薬剤耐性対策

Nathaniel H Park¹, Wei Cheng², Fritz Lai³

¹IBM Research-Almaden , 650 Harry Road , San Jose , California 95120 United States.

Journal of the American Chemical Society

|March 6, 2018

まとめ

新しい大分子化学療法薬は癌細胞膜を破壊することで薬剤耐性を克服しますこれらの自己組織化ナノ粒子は抵抗性および幹がん細胞に対する強力な活性を示し移行と抵抗性の発達を防止します

科学分野:

生物化学
材料科学
腫瘍学

背景:

薬剤耐性は化学療法における大きな課題です
ドクソルビシンのような既存の治療法は抵抗性を誘発し,抵抗性および幹細胞に対する効果は低い.

研究の目的:

自己組み立て可能なマクロ分子化学療法薬の新種の設計と評価
薬剤耐性がん細胞,がん幹細胞,および体内モデルに対する有効性を評価する.

主な方法:

合成されたカチオンのポリマーでナノ粒子に組み立てられる
薬剤耐性およびがん幹細胞を含む複数のがん細胞系に対して in vitro で試験した.
肝細胞がん患者からの異種移植マウスモデルで評価された.

主要な成果:

ナノ粒子に自己組み立てられたポリマーで強力な抗がん作用がある.
癌細胞膜溶解による薬剤耐性および癌幹細胞に対する有意な有効性が示された.
癌細胞の移動を阻害し,複数の経路を経て耐性を誘導しなかった.
ドクソルビシンとは異なり,異種移植のマウスモデルで抗がん効果を示した.

結論:

大分子化学療法が薬剤耐性を克服する有望な戦略です
この新しいナノ粒子のデザインは抵抗性のある癌細胞を効果的に標的にし駆除します
このアプローチは,抗がん治療の開発の新しいパラダイムを表しています.

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