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Updated: Feb 13, 2026

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
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Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System

Published on: August 1, 2016

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非正規のアミノ酸依存生物を生成するタンパク質におけるヒスティジンの機能的置換

Fei Gan1, Renhe Liu1, Feng Wang1

  • 1California Institute for Biomedical Research (Calibr) , La Jolla , California 92037 , United States.

Journal of the American Chemical Society
|March 7, 2018
PubMed
まとめ

研究者は,特定の非正規のアミノ酸を必要とする微生物を作り出す方法を開発し,ワクチンと生物学的封じ込めの安全性を高めました. これは,必須ヒスティジンアミノ酸を,機能的な類似体に置き換えることを含みます.

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Amino acids03:42

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Protein Organization01:13

Protein Organization

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Amino Acid Catabolism

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Amino Acid Biosynthetic Pathways

Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
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Mechanical Protein Functions

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Structural Protein Function

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