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単粒子の冷凍EM分析によるインスリン受容体-インスリン複合体の構造

Giovanna Scapin1, Venkata P Dandey2, Zhening Zhang2

  • 1Merck & Co., Department of Biochemical Engineering & Structure, 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, USA.

Nature
|March 8, 2018
PubMed
まとめ

インスリン受容体の活性化に関する構造的な洞察は,インスリン結合がどのように下流信号を発動させるかを明らかにします. これらの発見は 糖質の恒常性や 糖尿病などの関連疾患の理解を 進めているのです

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