EWS-FLI1は転写を増加させ,Rループを引き起こし,ユーイング肉腫におけるBRCA1修復を阻害する

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Updated: Feb 13, 2026

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
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Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

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Aparna Gorthi1,2, July Carolina Romero1,2, Eva Loranc2

  • 1Department of Cell Systems and Anatomy, University of Texas Health at San Antonio, San Antonio, Texas 78229, USA.

Nature
|March 8, 2018
PubMed
まとめ

ユーイング・サーコマ細胞はDNA修復機能が低下し,複製ストレスが増加し,化学療法に対する敏感性が説明されます. EWSR1タンパク質は,DNA損傷反応とRループ抑制において重要な役割を果たします.

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