イオン-炭化水素および/またはイオン-イオン相互作用:合成ホストにおける直接および逆ホフマイスター効果
Jacobs H Jordan1, Corinne L D Gibb1, Anthony Wishard1
1Department of Chemistry , Tulane University , New Orleans , Louisiana 70118 , United States.
Journal of the American Chemical Society
|March 14, 2018
まとめ
分極化アニオンはホフマイスターを誘発し,異なる結合部位を持つ宿主分子でホフマイスター効果を逆転させる. アニオン結合は電荷の衰弱,集積,降水を引き起こし,複雑な溶液の振る舞いを示します.
科学分野:
- 超分子化学
- 物理化学
- 溶液化学
背景:
- ホフマイスター効果は,タンパク質の溶解性および行動のイオン特異的な混乱を記述する.
- ホスト-ゲストの相互作用を理解することは,機能的な分子システムを設計するために不可欠です.
- 合成受容体におけるアニオン結合は溶液の性質を調節することができる.
研究 の 目的:
- ホスト・ゲストの複合性に対する偏極化アニオンの影響を調査する.
- 人工宿主体におけるホフマイスター効果を逆転させるためのメカニズムを明らかにする
- 宿主内の異なる部位へのアニオンの結合親和性と選択性を特徴付ける.
主な方法:
- 陽子核磁共振 (H NMR) スペクトロスコーピーは,結合相互作用を検出する.
- ダイナミック・ライト・スキャタリング (DLS) で粒子の大きさと集積を評価する.
- 降雨をモニターするための曇度測定.
主要な成果:
- アニオンは",柔らかい"非極性ポケットと"硬い"アンモニアイオンサイトの両方に比較可能な親和性を示します.
- 低濃度 (∼2 mM) のアニオン結合は,宿主-ゲスト結合におけるホフマイスター効果を誘導する.
- アニオン結合は電荷の減衰,集積,沈殿 (逆ホフマイスター効果) を引き起こす.
- 非極性ポケットを遮断すると 逆のホフマイスター効果が弱まります
結論:
- 分極化アニオンは,研究された宿主においてホフマイスター効果と逆のホフマイスター効果の両方を誘導する.
- 宿主の固有の結合部位はこれらの効果を媒介する上で重要な役割を果たします.
- アニオン誘発の降水は,特定の結合部位の相互作用によって調節される電荷の減衰と集積に関連している.
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