下肢 動脈 血栓 症 の リスク と 予後
Jens Sundbøll1, Katalin Veres1, Erzsébet Horváth-Puhó1
1Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
Circulation
|March 16, 2018
まとめ
下肢の動脈栓塞は 隠れた癌 特に肺癌の兆候です この状態は,一般的な癌の患者の生存率を悪化させ,癌の検出と予後におけるその重要性を強調しています.
科学分野:
- 血管医学
- 腫瘍学
- 流行病学
背景:
- 下肢の動脈血栓と癌のリスク/予後との関連はよく確立されていません.
- 静脈血栓塞栓症は癌の症状として知られており,動脈血栓症の調査を促しています.
- この研究は,下肢の動脈血栓と癌の間の未知の関連を扱っています.
研究 の 目的:
- 下肢動脈血栓症と診断された患者のがんリスクを調査する.
- 癌患者の死亡率に対する下肢動脈栓塞の予後効果を評価する.
- 下肢の動脈血栓が 隠された悪性腫瘍の早期マーカーとして機能するかどうかを判断する
主な方法:
- 1994年から2013年にかけてのデンマークの全国の医療記録を利用した.
- 第一次下肢動脈血栓症の患者を特定し,その後の癌の診断を追跡した.
- 標準化された発生比率とマッチングコホートを使用して,がんのリスクと死亡率の影響を評価しました.
主要な成果:
- 下肢動脈血栓症の6600人の患者のうち772人のがんが観察されました.
- 癌のリスクは,最初の6ヶ月 (SIR 3.28) で著しく上昇し,12ヶ月 (SIR 1.14) 以降も高いままでした.
- 最も強い関連性は肺癌と喫煙関連の癌で,動脈血栓症はいくつかの一般的な癌の死亡率を悪化させた.
結論:
- 下肢の動脈栓塞は 隠された癌 特に肺癌のマーカーです
- これは一般的ながん患者の死亡率の不良予後因子です.
- 下肢動脈血栓の早期発見は,未診断の悪性腫瘍を特定するのに役立ちます.
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