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関連する概念動画

Spinal Cord01:26

Spinal Cord

2.0K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
2.0K
The Spinal Cord01:54

The Spinal Cord

31.9K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.9K
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

3.6K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.6K
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

5.9K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.9K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

4.9K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
4.9K
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

1.9K
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
1.9K

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関連する実験動画

Updated: Feb 13, 2026

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
06:38

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

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マウスの発達中の脳と脊髄の単細胞プロファイリング

Alexander B Rosenberg1, Charles M Roco2, Richard A Muscat3

  • 1Department of Electrical Engineering, University of Washington, Seattle, WA, USA. alex.b.rosenberg@gmail.com gseelig@uw.edu.

Science (New York, N.Y.)
|March 17, 2018
PubMed
まとめ
この要約は機械生成です。

単細胞RNAのスケーラブルなシーケンシングのために スプリットプール結合ベースのトランスクリプトームシーケンシング (SPLiT-seq) を開発しました この方法では 発達中のマウスの脳と脊髄で 100種類以上の細胞を特定しました

さらに関連する動画

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
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Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples
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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples

Published on: April 11, 2025

1.5K

関連する実験動画

Last Updated: Feb 13, 2026

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
06:38

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

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Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

Published on: February 26, 2019

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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples
06:52

Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples

Published on: April 11, 2025

1.5K

科学分野:

  • 分子生物学
  • ゲノミクス
  • 神経科学

背景:

  • 単細胞RNAシーケンシング (scRNA-seq) は,複雑な生物学的システムを理解するために不可欠です.
  • 既存の scRNA-seq 方法は,固定されたサンプルとのスケーラビリティと互換性において課題に直面しています.

研究 の 目的:

  • 広範な細胞プロファイリングのためのスケーラブルで汎用的なscRNA-seq方法を開発する.
  • マウスの発達中枢神経系のトランスクリプトームを単細胞解像度で分析する.

主な方法:

  • スプリットプール結合ベースのトランスクリプトームシーケンシング (SPLiT-seq) を開発し,コンビネトリアルバーコードを使用した.
  • 生後マウスの脳と脊髄から156,049の単核トランスクリプトームを分析するためにSPLiT-seqを適用した.
  • 発達の軌道を調べるために 擬似時間の分析を用いた.

主要な成果:

  • 遺伝子発現パターンを基に 100種類以上の細胞を特定しました
  • 機能,地域特異性,分化段階によって特徴づけられた細胞タイプ.
  • 発現したトランスクリプションプログラムが 発現した 4つの主要な発達の系統が 発現した 4つの主要な発達の系統が 発現した

結論:

  • SPLiT-seqは,スケーラブルで効率的な単細胞トランスクリプトミックプロファイリングを可能にします.
  • 産後初期の中枢神経系発達の詳細なスナップショットを提供しています
  • 他の複雑な多細胞系を 総合的に分析するための方法を提供する.