不飽和化合物の空気による酸化

Hai-Jun Zhang¹, Alexander W Schuppe², Shi-Tao Pan¹

¹CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis , Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.

Journal of the American Chemical Society

|March 17, 2018

まとめ

新しい銅触媒による酸化方法は,不飽和エステルやその他の化合物を効率的に変換します. この多用途な反応は,複雑な分子を合成するための幅広い範囲と高い選択性を提供します.

科学分野:

有機化学
カタリシス
酸化反応

背景:

ビニロゲスの酸化は有機合成における重要な変換である.
温和で効率的な触媒システムを開発することは依然として課題です.

研究の目的:

銅触媒による新型の有酸素酸化方法の開発.
この新しい方法論の範囲と限界を探求する.

主な方法:

不飽和エステルの銅触媒による有酸素酸化.
ベースおよび潜在的なリガンドとしてテトラメチルグアニジン (TMG) を利用した.
実験データを用いてメカニズム的経路を調査した.

主要な成果:

β,γ-およびα,β-不飽和エステルの軽い,操作的に単純な酸化を達成した.
広い基板範囲,良い収穫量,そして優れた選択性を示した.
複雑な天然製品の合成に成功しました

結論:

開発された方法は,ビニロゲスの酸化のための強力なツールを提供します.
触媒システムは高機能群の耐性と選択性を表している.
この方法は,様々な不飽和化合物や複雑な基板に適用できます.

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