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ヘテロディメリックABCエクスポーターにおける大規模コンフォームトランジションの原子化メカニズム

Hendrik Göddeke1, M Hadi Timachi2, Cedric A J Hutter3

  • 1Theoretical Chemistry, Faculty of Chemistry and Biochemistry , Ruhr-University Bochum , 44780 Bochum , Germany.

Journal of the American Chemical Society
|March 17, 2018
PubMed
まとめ

この研究はATP結合カセット (ABC) トランスポーターTM287/288の原子機構を明らかにした. ATP結合が構造変化を駆動し,トランスポーターを内向きから外向きの状態に遮断された中間体を通して移動させることを示しています.

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