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Updated: Feb 3, 2026

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
11:08

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device

Published on: September 19, 2025

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マルチプレックスド プロテオーム ダイナミクス プロファイリング タンパク質 ホメオスタシスを制御するメカニズムを明らかにする

Mikhail M Savitski1, Nico Zinn2, Maria Faelth-Savitski2

  • 1Cellzome GmbH, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany; Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Cell
|March 20, 2018
PubMed
まとめ

タンパク質の分解と合成を研究する 新しい方法である 複合タンパク質ダイナミクスプロファイリング (mPDP) を開発しました mPDPは細胞がタンパク質のレベルを制御する方法を明らかにし,生物学的プロセスと治療戦略の洞察を提供します.

キーワード:
HSP90 についてJQ1 についてプロタック劣化するエストロゲン受容体マススペクトロメトリー作用メカニズムタンパク質の売上高プロテオスタシス

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関連する概念動画

Mechanical Protein Functions01:58

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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What is Homeostasis?01:16

What is Homeostasis?

Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
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pH Homeostasis01:31

pH Homeostasis

Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
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Mechanical Protein Function01:58

Mechanical Protein Function

No description available
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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