ヒトの配列データを分析した結果, 古代デニソワ人の2つのパルスが発見された
Sharon R Browning1, Brian L Browning2, Ying Zhou1
1Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Cell
|March 20, 2018
まとめ
ネアンデルタール人やデニソワ人のような 古代の人類と交配しました ユーラシアとオセアニアの集団で少なくとも2つの異なるデニソヴァン混入の出来事を明らかにしました
科学分野:
- 人類の進化
- 集団遺伝学
- 古代のDNA分析
背景:
- 解剖学的に現代のヒト (ホモ・サピエンス) は,ネアンデルタール人とデニソワ人を含め,古代のヒトと交配した.
- ネアンデルタール人とデニソワ人の 配列化されたゲノムは 現代の人類の内向的な 古代の遺伝物質の識別を可能にしました
- 参照ゲノムなしで内侵入を検知することは,より遠い古代の個体からセグメントを識別するための利点を提供します.
研究 の 目的:
- 古い侵入を検出するための新しい基準のない方法を適用する.
- ユーラシアとオセアニアの全ゲノム配列の大規模なデータセットの内進パターンを分析する.
- 現代のヒト集団におけるデニソワ人の混入事件の数と性質を調査する.
主な方法:
- 古い侵入を検出するための基準のない方法の開発と適用.
- ユーラシアとオセアニアの個人から5639の全ゲノム配列の分析
- アルタイ・デニソワンの参照ゲノムに対するデニソワンの祖先成分の比較分析.
主要な成果:
- デニソワ人の祖先は東アジア,南アジア,パプアニューギニアの集団で発見されました.
- デニソワ人の祖先は 少なくとも2つの異なる構成要素で構成されています
- これらの成分は,配列化されたアルタイ・デニソヴァンと異なるレベルの類似性を示し,複数の添加事件を示唆しています.
結論:
- 少なくとも2つのデニソワ人が 解剖学的に現代の人間と 混じった事例があります
- この混合物には,アルタイのデニソヴァン個体と異なる程度に 関連したデニソヴァン個体が含まれていた.
- 基準のない方法は,より密接な関係を持つ古人のヒト類を含む古人の侵入を特定するのに有効です.
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