占領下のパレスチナの複数の輸血患者における赤血球アロ抗体:試験試験

Ahmad Yaseen¹, Sa'd Suleiman¹, Omar Abu Zenah¹

¹Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, West Bank, occupied Palestinian territory.

Lancet (London, England)

|March 20, 2018

まとめ

ウェストバンクで複数の輸血を受けた患者の15%が主にRhとKellの血液型に対するアロ抗体を発症した. これは,合併症を防ぐために抗原に適合する輸血の必要性を強調しています.

科学分野:

血液学
免疫学
輸血医学

背景:

赤血球の輸血はタラセミアと状血球疾患の管理に不可欠です.
しかし,多重輸血を受けた患者は免疫の危険性があり,輸血反応を引き起こします.
アロ抗体は将来の輸血と患者のケアを複雑にする可能性があります.

研究の目的:

多重輸血患者におけるアロ抗体の頻度と種類を決定する.
西岸北部の患者における予防接種率を評価する

主な方法:

西岸の3つのタラセミアセンターで実施されたパイロット研究.
標準的な実験室パネルを用いたアルロ抗体のスクリーニングと識別.
タラセミアまたは状細胞貧血を患った131人の患者から収集されたデータ

主要な成果:

患者の15% (20人中131人) がアロ抗体を発症した.
大半の抗体はRh血型系 (65%) であり,抗D,抗E,抗RhC,抗Cが含まれていた.
抗ケル抗体は,免疫された患者の35%で確認された.

結論:

この地域では,複数の輸血を受けた患者で,アル・免疫化の有意な流行がある.
RhとKellの血液型系抗体は主要なタイプです.
拡張赤血球フェノタイプ化と抗原マッチング輸血を実施することは,アロ免疫化を緩和するために極めて重要です.

さらに関連する動画

09:12

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry

Published on: January 12, 2018

15.5K

11:27

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay

Published on: February 7, 2025

1.1K

関連する概念動画

01:15

Blood Transfusion

2.4K

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

2.4K

02:45

Blood Transfusion and Agglutination

14.9K

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

14.9K

01:21

Pilot and Numeric Relaying

496

Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:

496

01:20

Design Example: Capacitance Multiplier Circuit

1.6K

In integrated circuit technology, a capacitance multiplier is often utilized to produce a larger capacitance value when a small physical capacitance falls short. This is achieved by a circuit that multiplies capacitance values by a factor of up to 1000, such that a 10-pF capacitor can replicate the performance of a 100-nF capacitor.
The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.

1.6K

01:26

Blood Studies I: ABG and VBG

1.3K

Blood studies are critical in the medical field, enabling healthcare professionals to assess a patient's health status accurately. This page will focus on two significant blood studies: Arterial Blood Gas (ABG) and Venous Blood Gas (VBG).
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...

1.3K

01:23

Red Algae

1.0K

Red algae, also known as rhodophytes, are primarily found in marine environments, though some species inhabit freshwater and terrestrial ecosystems. These organisms exist in both unicellular and multicellular forms, with some multicellular varieties reaching macroscopic sizes.As phototrophic organisms, red algae contain chlorophyll a; however, their chloroplasts lack chlorophyll b. Instead, they possess phycobiliproteins, which serve as major light-harvesting pigments, similar to those found in...