パラブラキアルCGRPニューロンによる危険の符号化
Carlos A Campos1, Anna J Bowen1, Carolyn W Roman1
1Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Nature
|March 22, 2018
まとめ
パラブラキア核のカルシトニン遺伝子関連ペプチドニューロン (CGRPPBNニューロン) は脅威をシグナルする. これらのニューロンは 危険によって活性化され 食事中に抑制され 害を制限する行動を促します
科学分野:
- 神経科学
- 行動生物学
- 感覚生理学
背景:
- 生き残るには様々な脅威に対して 適切な対応が必要です
- パラブラキアル核 (PBN) のカルシトニン遺伝子関連ペプチド (CGRP) ニューロンは,飽和と恐怖の行動の処理に関与しています.
- CGRPPBNニューロンによるこれらの異なるプロセスの正確なエンコーディングメカニズムは,まだ完全に理解されていません.
研究 の 目的:
- CGRPPBNニューロンの脅威と餌の行動に関連する感覚信号のエンコーディングにおける役割を調査する.
- CGRPPBNニューロンが適応行動状態にどのように寄与するかを決定する.
主な方法:
- マウスの個別のCGRPPBNニューロンのインビボカルシウムイメージング.
- 有害な皮膚および内臓刺激に対する神経活動の記録
- ニューロンの反応を評価する. 食事や飽和,新しい食物への反応と, 条件付きの恐怖刺激.
- CGRPPBNのニューロンサイレンスによる行動効果の評価
主要な成果:
- ほとんどのCGRPPBNニューロンは有害な刺激 (皮膚および内臓) によって活性化されます.
- これらのニューロンは食事中に抑制され,満腹時に活性化され,過食を防ぐ役割を示唆しています.
- CGRPPBNニューロンは,新しい食品の消費と,ネガティブな経験 (フットショック) に関連する聴覚のシグナルに反応する.
- CGRPPBNニューロンを静止すると 食物新恐怖症と条件付き恐怖反応が減少します
結論:
- CGRPPBNニューロンは,主感覚の危険信号を伝達するのに不可欠です.
- これらのニューロンは 潜在的な脅威からの害を軽減する 感情的行動状態を促進する上で重要な役割を果たします
- CGRPPBNニューロンは 感覚情報を統合して 適応的生存行動を編成します
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