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Updated: Feb 13, 2026

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肥満における肝細胞が分泌するDPP4は脂肪の炎症とインスリン抵抗性を促進する

Devram S Ghorpade1, Lale Ozcan1, Ze Zheng1

  • 1Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA.

Nature
|March 22, 2018
PubMed
まとめ

肥満は肝細胞のディペプチジルペプチダゼ4 (DPP4) の分泌を促進し,XA因子と共に内臓脂肪組織マクロファージ (ATM) を炎上させ,インスリン抵抗性を引き起こします. この経路をターゲットにすることで,経口 DPP4 阻害剤を超える明確な代謝効果が得られます.

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