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Updated: Feb 13, 2026

A Fluorescence-based Assay of Phospholipid Scramblase Activity
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哺乳類のTPC1チャネルの電圧とフォスフォリピドの活性化に関する構造的洞察

Ji She1,2, Jiangtao Guo3, Qingfeng Chen1,2,4

  • 1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA.

Nature
|March 22, 2018
PubMed
まとめ

マウスTPC1 (MmTPC1) の構造的な洞察は,この電圧依存ナトリウムチャネルがどのように開くかを明らかにします. フォスファチチドリノシトール3,5-二酸化物 (PtdIns(3,5) P2) の結合と膜脱極化は,MmmTPC1ゲートとイオン選択性を調節する.

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