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幼少期の経験が ネズミの神経ゲノムの構造的変化を誘発する
Tracy A Bedrosian1, Carolina Quayle2, Nicole Novaresi2
1Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. tbedrosian@salk.edu gage@salk.edu.
Science (New York, N.Y.)
|March 24, 2018
まとめ
母の介護のような 幼少期の経験は 脳のゲノムモザイクに影響します 高い母体ケアにより,マウスヒポキャンプスの移動性遺伝子要素,特にLINE-1レトロトランスポーザントの動員が減少します.
科学分野:
- 神経科学
- 遺伝学
- エピジェネティクス
背景:
- 脳は発達中の体内の変異により ゲノムモザイクを呈する.
- レトロトランスポゾンなどの 移動性遺伝子は この脳モザイクに寄与します
- リトロトランスポーゼーションは,環境刺激に対する神経の可塑性のメカニズムであると仮定されています.
研究 の 目的:
- ネズミの脳におけるレトロトランポゾン動員に対する母親の介護の変動の影響を調査する.
- 母の介護とレトロトランスポゾン活動とを結びつけるエピジェネティックメカニズムを探る
主な方法:
- レトロトランポゾン動員を定量化するために,ドロップレットデジタルポリメラーゼ連鎖反応 (ddPCR) が使用された.
- 特定の結合部位 (YY1) でのDNAメチル化パターンの分析とデノボメチルトランスフェラーゼ (DNMT3a) の発現が行われました.
主要な成果:
- 母親の介護における自然的な変動は,ヒポカンプスの長い核元素-1 (LINE-1またはL1) リトロトランスポーズンの動員に大きく影響した.
- 母親のケアを増やすことは,L1蓄積の阻害と関連していました.
- 母親の介護はYY1結合部位でのDNAメチル化に影響を与え,DNMT3aの発現を変化させた.
結論:
- 早期の生活経験,特に母親の介護は,L1レトロトランポゾンの調節を通して体内のゲノム変異を誘導することができます.
- この研究は 脳の環境要因と ゲノムダイナミクスとの間に 機械的なつながりを示しています
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