リンパ節転移 は 局所 的 な 血管 に 侵入 し,その 結節 から 出 て 遠く の 臓器 に 寄生 する
Ethel R Pereira1, Dmitriy Kedrin1,2, Giorgio Seano1
1Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital (MGH) Cancer Center, MGH and Harvard Medical School (HMS), Boston, MA 02114, USA.
まとめ
リンパ節にある癌細胞は 体の遠い部位に広がる可能性があります リンパ節転移が新しい腫瘍の形成につながることを示すため,この研究はマウスで新しい技術を使用しました.
科学分野:
- 腫瘍学
- 癌の転移に関する研究
- 分子生物学
背景:
- リンパ節転移は 侵襲的な癌と 患者の悪い結果と関連しています
- リンパ節転移が遠隔感染源としての役割は議論されている.
研究 の 目的:
- リンパ節の転移中の癌細胞が遠くの臓器に広がるかどうかを調査する.
- リンパ節転移から発生した癌細胞の運命を決定する.
主な方法:
- 癌細胞を移植したマウスモデル (乳がん,状細胞がん,メラノーマ) を利用した.
- リンパ節内の転移細胞を標識し追跡するために photoconvertible protein Dendra2を使用しました.
- リンパ節の血管の侵入と 遠隔地の植民を観察した
主要な成果:
- リンパ節転移による癌細胞のサブセットが 局所的な血管に侵入した.
- これらの細胞は血流に侵入し 遠隔の転移,特に肺に広がった.
- リンパ節転移のメカニズムを臨床前モデルで示した.
結論:
- マウスモデルではリンパ節転移が 癌の遠隔拡散の源として機能する.
- このメカニズムがヒトの癌患者で有効かどうかを確認するには,さらなる研究が必要である.
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