ヒトの臓β細胞の空間時間的多尺度モデル構築における機会と課題
Jitin Singla1, Kyle M McClary2, Kate L White3
1Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; Department of Biological Sciences, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.
Cell
|March 24, 2018
まとめ
ユカリオット細胞の ダイナミックで多面的なモデルを作ることは 科学的な大きな課題です このビジョンは 糖尿病の研究と医療を進めるための 臓ベータ細胞の 時空モデルを示しています
科学分野:
- 計算生物学
- システム生物学
- バイオ物理学
背景:
- ユカリオット細胞全体をスケールで動的にモデル化することは大きな課題です.
- このようなモデルは 生物学の研究に革命をもたらし 医療の進歩を促すでしょう
- 生物学,化学,物理学,コンピュータ科学を組み合わせた学際的なアプローチは不可欠です.
研究 の 目的:
- 臓のベータ細胞の空間時間的な多次元モデルを提示する.
- 糖尿病の病原性を理解し制御するための枠組みを確立する.
- コミュニティ主導の実験・モデリング方法の開発の機会を強調する.
主な方法:
- データ収集のための新しい実験技術を開発する.
- 先進的なコンピューティング・モデリングのアプローチを作成します.
- 原子レベルから細胞レベルまで 複数のスケールのデータを統合します
主要な成果:
- 臓のベータ細胞モデルのための提案された枠組み.
- マルチスケール・セル・モデリングにおける主要な課題と機会の特定
- 分野間の協力のためのロードマップ
結論:
- パンクレアベータ細胞の包括的,ダイナミックな,マルチスケールのモデルは達成可能である.
- このようなモデルは 糖尿病の研究と治療に大きな影響を与えます
- この野心的な目標を実現するためには,地域全体の努力が不可欠です.
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