フラビン・モノオキシゲネーゼ生成のN-ヒドロキシピペコリック酸は,植物性免疫の重要な要素である
Michael Hartmann1, Tatyana Zeier1, Friederike Bernsdorff1
1Institute for Molecular Ecophysiology of Plants, Department of Biology, Heinrich Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Cell
|March 27, 2018
まとめ
植物は,全身の獲得抵抗性 (SAR) を通して,広範囲の免疫を発達させる. この研究は,パイプコリック酸 (Pip) がSARの重要な調節体であるN-ヒドロキシピペコリック酸 (NHP) に変換されることを示しています.
科学分野:
- 植物病理学
- 分子生物学
- 生物化学
背景:
- 植物は,最初の微生物接触後に病原体に対する全身耐性 (SAR) を表します.
- アラビドプシス・タリアナのSARは,ライシン・カタボライトであるパイプコリック酸 (Pip) とフラビン依存モノオキシゲナーゼ1 (FMO1) を含む.
研究 の 目的:
- 植物免疫におけるパイプコリック酸 (Pip) とフラビン依存モノキシゲネーゼ1 (FMO1) の役割を調査する.
- SARの文脈でFMO1の生化学的機能を特定する.
主な方法:
- 植物内および体内生化学測定法
- トランスクリプション再プログラム分析
- fmo1変異体におけるN-ヒドロキシピペコリック酸 (NHP) の外因的適用
主要な成果:
- 増加したPipは,SARを模倣するFMO1依存の転写変化を誘発する.
- FMO1はPipをN-ヒドロキシピペコリック酸 (NHP) に変換する触媒である.
- NHPは,FMO1欠乏した植物免疫をシステム的に蓄積します.
結論:
- 病原体誘導性L-Lysの分解経路は,NHPを生成する.
- NHPは植物における全身耐性の重要なレギュラーである.
- NHPは,細菌やオオミセト病原体に対する植物免疫の強力な誘発剤として作用する.
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