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多発性硬化症
Alan J Thompson1, Sergio E Baranzini2, Jeroen Geurts3
1Queen Square MS Centre, UCL Institute of Neurology, London, UK; NIHR University College London Hospitals Biomedical Research Centre, London, UK.
Lancet (London, England)
|March 27, 2018
まとめ
多発性硬化症 (MS) の理解には 遺伝的要因や ビタミンDの不足などの環境要因が含まれます 早期診断と個別化された治療計画により MS患者の生活の質が向上します
科学分野:
- 神経学
- 免疫学
背景:
- 多発性硬化症 (MS) は重要な障害を持つ複雑な神経疾患です.
- 遺伝子と環境要因は 低ビタミンD,喫煙,肥満などの原因で 発症することがあります
研究 の 目的:
- 多発性硬化症の現在の理解と管理の概要を提示する.
- MSの診断,治療,患者ケア戦略の進歩を強調する
主な方法:
- 多発性硬化症の病因,診断,治療に関する現在の文献のレビュー.
- 神経画像と脳脊髄液の分析を含む診断基準の組み込み
- 再発性寛解性MSの治療ガイドラインの検討
主要な成果:
- 早期診断は,臨床的に孤立した症候群の確立された基準によって促進されます.
- 再発性・寛解性MSには様々な経口療法や注射療法があります.
- パーソナライズド・メディカルアプローチは 臨床ガイドラインで支持されています
結論:
- ウェルネスと併発症管理に焦点を当てた総合的な管理プログラムは,MS患者の生活の質を改善するために不可欠です.
- 将来の研究は,進行性MSの治療のために神経保護とリミエリネーションに焦点を当てるべきです.
- 効果と副作用のプロファイルに基づいて治療の選択を最適化することが不可欠です.
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