視覚皮質からの単細胞投影の論理
Yunyun Han1,2,3, Justus M Kebschull4,5, Robert A A Campbell3
1Department of Neurobiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nature
|March 29, 2018
まとめ
マウスの脳内の個々のニューロンは 複数の領域に広がり 単一標的ニューロン通信という考えに 異議を唱えます この発見は 脳の様々な領域で 複雑な情報を共有することを明らかにし 神経経路の理解に影響を与えます
科学分野:
- 神経科学
- システム神経科学
- 計算神経科学
背景:
- 新皮質のコミュニケーションは軸索の投影に依存しますが,個々のニューロン投影パターンはほとんど知られていません.
- 情報の伝達を理解するには ニューロンの標的を体系的に特徴づける必要があります
研究 の 目的:
- マウスの主視野皮質の個々のニューロンのプロジェクションパターンを体系的にマッピングする.
- 個々のニューロンが単一か複数の皮質や皮質下部に 発射されているかどうかを判断する.
主な方法:
- 脳全体の光による軸索追跡を 活用した.
- 591 個のニューロンに対して,遺伝子的にバーコードされたニューロンの高通量DNAシーケンシング (MAPseq) を採用した.
主要な成果:
- 少なくとも18の皮質と皮質下部を標的とした 非常に多様で異なった投影を発見した.
- ほとんどのニューロンが多重な皮質領域に ランダムでない組み合わせで投影されていて 異なるニューロンサブクラスを示唆しています
- "ニューロン"と"ターゲットエリア"のシステムではないことを示した.
結論:
- 個々の皮質ニューロンは 標的領域のサブセットで 信号を共有します
- 神経信号は同時に複数の機能的経路に寄与し 複雑な情報共有モデルを示しています
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