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グルコ-1H-イミダゾール:アゾール型β-グルコシダース阻害剤の新種

Sybrin P Schröder, Liang Wu1, Marta Artola

  • 1Department of Chemistry, York Structural Biology Laboratory , University of York , Heslington, York YO10 5DD , United Kingdom.

Journal of the American Chemical Society
|March 31, 2018
PubMed
まとめ

新しいGluco-1H- imidazole化合物は,Gaucher病に不可欠なGBA1酵素を効果的に阻害し,強力なグルコシダース阻害剤として作用します. これらの新しい阻害剤は,他の関連酵素に影響を与えることなく,治療開発の有望性を示しています.

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