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Updated: Feb 12, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
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BCL11Aによる直接プロモーター抑制は,胎児から成人ヘモグロビンスイッチを制御する

Nan Liu1, Victoria V Hargreaves1, Qian Zhu2

  • 1Cancer and Blood Disorders Center, Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Cell
|April 3, 2018
PubMed
まとめ

BCL11Aは胎児のヘモグロビン (HbF) 遺伝子発現を直接抑制し,成人ヘモグロビン (HbA) への切り替えを促します. このメカニズムは,グロビン遺伝子のスイッチングを調節するために重要な,γ-グロービンプロモーターの特定のDNAモチーフを伴う.

キーワード:
BCL11ACUT&RUN (カット&ラン)DNA結合デジタルゲノム・フットプリント遺伝子編集ヘモグロビンタンパク質結合マイクロアレイ抑圧亜鉛指

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