CRMP2結合化合物であるエドナーピクマレートは,脳損傷からの運動機能の回復を加速する
Hiroki Abe1, Susumu Jitsuki1, Waki Nakajima1
1Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
Science (New York, N.Y.)
|April 7, 2018
まとめ
エドナーピクマレートは,シナプス可塑性を高めることで,脳損傷後の運動機能の回復を加速します. この神経可塑性増強剤は 患者のリハビリテーションの成果を 改善することを示しています
科学分野:
- 神経科学
- 薬理学について
- 神経学的リハビリテーション
背景:
- 脳卒中のような脳損傷は 生活の質に深刻な影響を及ぼします
- 有効な薬によるリハビリテーション戦略が欠けている.
- 神経損傷からの回復を加速することは 満たされていない重要なニーズです
研究 の 目的:
- 運動機能の回復を加速させるためのエドナーピクマレアートの治療の可能性を調査する.
- 神経の可塑性を促進するエドナーピクマレアートの作用メカニズムを解明する.
主な方法:
- エドナーピク・マレアートは,運動皮質の凍結傷を負ったマウスと,内部カプセル出血の非ヒト霊長類に投与された.
- 運動機能の回復と訓練によるリハビリテーションの評価
- コラプシン応答媒介タンパク質2 (CRMP2) とα-アミノ-3-ヒドロキシ-5-メチル-4-イソクサゾール-プロピオン酸 (AMPA) 受容体の作用を研究した.
主要な成果:
- エドナーピクマレアートは,訓練に依存した皮質の再編成により,マウスの運動機能の回復を著しく加速した.
- CRMP2欠乏したマウスの回復を向上させなかったため,化合物の有効性はCRMP2に依存した.
- エドナーピク・マレアートは,内部カプセル出血後の非人間霊長類における運動機能の回復を強めた.
結論:
- エドナーピク・マレアートは,経験主導のシナプスAMPA受容体伝達を促進することによって,神経の可塑性増強剤として作用する.
- この化合物は,脳損傷後のリハビリテーションを加速させる臨床的に有効な薬剤としての可能性を証明しています.
- CRMP2と神経の可塑性をターゲットにすることで 神経の回復に 有望な治療法が生まれます
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