癌ゲノミクスの始まりの終わりにおける腫瘍学的プロセスに関する展望
Li Ding1, Matthew H Bailey2, Eduard Porta-Pardo3
1Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA.
Cell
|April 7, 2018
まとめ
癌ゲノムアトラス (TCGA) プロジェクトは11,000以上の腫瘍を 徹底的に分析し 癌の主要な分子要因を明らかにしました この研究は,突然変異,遺伝子発現,腫瘍の微小環境に関する発見を集約し,将来のがん研究と臨床応用を導き出します.
科学分野:
- 腫瘍学
- ゲノミクス
- 癌 生物学
背景:
- 癌ゲノムアトラス (TCGA) プロジェクトは,ヒトの癌のゲノム変異を体系的に特徴づけています.
- ゲノム解析が完了しました ゲノム解析が完了しました
- 腫瘍形成の分子基盤を理解することは 癌治療の進歩に不可欠です
研究 の 目的:
- TCGA パンガンサー・アトラスの調査結果に基づいて,腫瘍発生に関する現在の理解をまとめます.
- 体内の変異,生殖系変異,腫瘍内の相互作用を研究する.
- 腫瘍ゲノムとエピジェノームがトランスクリプトームとプロテオームに与える影響と,腫瘍と微小環境の関係を調査する.
主な方法:
- ソマティックドライバ変異と生殖系統の病原性変異の分析
- ゲノムとエピジェノミックデータをトランスクリプトミックとプロテオミックプロファイルと統合する.
- 腫瘍と微小環境の相互作用とその臨床的影響の検討
主要な成果:
- 癌の形成を左右する主要な分子過程を特定する.
- 腫瘍ゲノムとエピジェノームが遺伝子発現とタンパク質生成にどのように影響するか解明する.
- 標的治療と免疫療法における腫瘍の微小環境とその関連性に関する洞察
結論:
- TCGA パンガンサー・アトラスは,がんの分子過程の基礎的な理解を提供します.
- 発見は,稀な/一般的な腫瘍,原発性/再発性がん,および多様な祖先に関する将来の研究を導くでしょう.
- 結果は癌の診断と治療における ゲノムシーケンシングの臨床応用に役立つでしょう
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