親の行動の基礎となる機能的な回路アーキテクチャ

Johannes Kohl¹, Benedicte M Babayan², Nimrod D Rubinstein¹

¹Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.

Nature

|April 13, 2018

まとめ

脳の特定のニューロンが

科学分野:

神経科学
行動神経科学
神経生物学

背景:

哺乳類の子孫の生存と健康には育児が不可欠です
複雑な育児行動を調整する神経回路は十分に理解されていません
中間視前領域 (MPOA) は親のケアに関与する重要な脳領域です.

研究の目的:

マウスにおける育児行動の調整における,中央前視領域 (MPOA^Gal) のガランリン発現ニューロンの役割を調査する.
MPOA^Galニューロンがどのようにして様々なインプットを統合し脳の異なる領域に投影し育児の特定の側面を制御するかを理解する

主な方法:

マウスのMPOA^Galニューロン活動と投影を操作するために光遺伝学を使用しました.
ニューロンの活動を記録し特定の親の行動と関連付けました
MPOA^Galニューロンへの様々な脳領域からのインプットの統合を調査し,性別と生殖状態を考慮した.

主要な成果:

MPOA^Galニューロンはすべての育児行動で活性化します
MPOA^Galニューロンのサブセットは異なる脳領域に発射され特定の育児成分によって選択的に活性化されます
オプトジェネティックな操作によって育児の特定の側面が変化し機能的な専門性を示しました

結論:

MPOA^Galニューロンは育児の異なる要素を制御する機能的に特化したプールに編成されています
この組織は複雑な社会行動を生み出すための回路レベルのモデルを提供します
発見は親のケアと社会的行動の調整の神経的基盤の洞察を提供しています

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