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Updated: Feb 11, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

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クリアセル腎臓細胞がんの進化における画期的な出来事のタイミング: TRACERx腎臓

Thomas J Mitchell1, Samra Turajlic2, Andrew Rowan3

  • 1Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Academic Urology Group, Department of Surgery, Addenbrooke's Hospitals NHS Foundation Trust, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK.

Cell
|April 17, 2018
PubMed
まとめ

クリアセル腎臓がん (ccRCC) は,染色体3pの喪失とTERT変異を含む. この一般的なゲノム現象は 若い時に起こりますが 腫瘍の発達に先立って 早期の介入の可能性があります

キーワード:
癌の進化クロモトリプシス明らかに細胞性腎臓がん

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Drug Elimination: Non-Renal Routes

The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
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